Selenium is used as a dietary supplement mainly in the treatment of selenium deficiency affecting young women and children with ?Keshan disease. It is also used for treatment of osteoarthiritis associated with poor selenium levels in body called Kashin-Beck Disease. Selenium supplements are also used in patients with HIV/ AIDS to maintain the adequate selenium levels.

Selenium is a trace element that is essential in small amounts in the body. Selenium is important in the functioning of selenium dependent chemical (enzymes) in the body called as selanoproteins. Selenium is an integral part of glutathione peroxidases (GPx) that act as potent antioxidant (substance that protects against cell damage) by neutralizing the free radicals (waste products formed in the body during energy production) such as reactive oxygen and nitrogen species. Thus selenium participates in vital redox reactions of the body. Also, a selenoprotein (iodothyronine deiodinases) is essential for the conversion of thyroxine (T4) to the biologically active thyroid hormone triiodothyronine (T3) thereby indicating the importance of selenium in thyroid hormone functioning.

Gastrointestinal disturbances, Irritability, Fatigue, Chronic selenium toxicity with symptoms such as hair and nail brittleness and loss, Garlic breath odor, Skin rashes, No side effects are found at the recommended intakes, And nervous system abnormalities.

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