Rofecoxib is used to relieve the pain and inflammation of osteoarthritis (a type of joint disease that causes stiffness, pain and loss of joint movement) and rheumatoid arthritis (inflammatory disorder that typically affects the small joints in hands and feet). It is also used to treat menstrual pain, migraine headache attacks with or without aura.

Rofecoxib belongs to a group of medicines called COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs). It works by inhibiting certain chemical called prostaglandin which is responsible for pain and inflammation.

Serious allergic reactions, Nausea, Vomiting and upset stomach, Jaundice and liver failure., Heartburn, Heart attacks, Stomach and intestinal bleeding, Including hepatitis, Tiredness, High blood pressure, Severe liver problems, Swelling of the legs and/or feet, Stomach pain, Respiratory infections, Diarrhea, Back pain, Dizziness, Headache, Kidney failure and worsening of chronic kidney failure, Urinary tract infection

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