PRESCRIPTION MEDICATION

Nicotine

Tobacco withdrawal.

Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of nicotine. Nicotine also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.

Respiratory arrest, Increased blood lactate, Paresthesias, Hyperpnea, Faintness, Sweating, Hyperglycemia, Tremor, Palpitation, Epileptic seizures, Hypoinsulinemia, Pallor.

2BACONIL TTS 10/7MG PATCH 7'S
Rs. 595.00 per STRIP
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2BACONIL TTS 30/21MG PATCH 7'S
Rs. 840.00 per STRIP
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2BACONIL TTS 20/14MG PATCH 7'S
Rs. 665.00 per STRIP
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QUITSURE 4MG TABLET 10'S
Rs. 39.80 per STRIP
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QUITSURE 2MG TABLET 10'S
Rs. 60.00 per STRIP
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NICOGUM 4MG CHEW GUM TABLET 10'S
Rs. 75.00 per Strip
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