Hydroxyprogesterone is used to reduce risk of preterm birth (delivery in <37 weeks of pregnancy) in women pregnant with one baby (singleton pregnancy) and who have delivered a premature baby in the past.

Hydroxyprogesterone belongs to a class of medications called progestins (female hormones). It is a synthetic form of the female hormone progesterone, however the exact mechanism by which it reduces risk of preterm birth is not known.

Itching of skin ; blood clots that may cause swelling, Bruising or a hard bump at the injection site; red, Pain, Skin rash, Itching, Diarrhea., Redness and pain in the leg; nausea, Swelling, Itchy bumps on skin

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