Diosmin Flavonoids

It is used to treat patient's with hemorrhoids (swollen and inflamed veins in anus), venous stasis (poor circulation in the legs), and bleeding (hemorrhage) in the eye or gums.

Inflammatory reactions are trigged by chemical and biological mediators, such as arachidonic acid derivatives (prostaglandins, leukotrienes, or tromboxanes), vasoactive amines (histamine or serotonin), and oxygen free radicals (superoxide ion, hydrogen peroxide). In venous inflammation, histamine causes vasodilatation ; and PGE2, histamine, and free radicals increase membrane permeability . Diosmin acts by inhibiting the enzyme phosphodiesterase, increasing intracellular cyclic adenosine monophosphate (cAMP) and consequently reducing the level of the main biochemical mediators of inflammation prostaglandin E2 and F2 (PGE2, PGF2), thromboxane B2 (TXB2), and oxygen free radicals.

Gi upset, Autonomic complaints.

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