Calcium Folinate

As an antidote to methotrexate, Folate deficiency anaemia, Megaloblastic anaemia, Nausea and vomiting, Suspected methotrexate overdosage, To counteract the folate-antagonist action of methotrexate.

Calcium folinate enters the cells as 5-methyl tetrahydrofolate and supplies the cofactor blocked by methotrexate. It stabilises the binding of 5-dUMP and thrymidylate synthetase, enhances flourouracil activity and neutralises the effects of folic acid antagonists such as methotrexate but increases those of 5-fluorouracil.

Hypersensitivity reactions., Anaphylactoid reactions, Urticaria, Fever

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