PRESCRIPTION MEDICATION

Acetylsalicylic Acid

Increased risk of blood clotting, Myocardial infarction, coronary bypass, transluminal angioplasty, strokes, transient ischaemic attack. Analgesic (Headache, backache, myalgia, joint pain, toothache, neuralgias, dysmenorrhoea), Antipyretic.

The platelet aggregation-inhibiting effect of acetylsalicylic acid specifically involves the compound's ability to act as an acetyl donor to cyclooxygenase; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Irreversible acetylation renders cyclooxygenase inactive, thereby preventing the formation of the aggregating agent thromboxane A2 in platelets. Since platelets lack the ability to synthesize new proteins, the effects persist for the life of the exposed platelets (7-10 days). Acetylsalicylic acid may also inhibit production of the platelet aggregation inhibitor, prostacyclin (prostaglandin I2), by blood vessel endothelial cells; however, inhibition prostacyclin production is not permanent as endothelial cells can produce more cyclooxygenase to replace the non-functional enzyme.

Asthma, Angioneurotic edema, Vertigo, Nausea, Dyspepsia, Vomiting, Gastric erosion, Gi bleeding, Hepatitis, Rhinitis, Bleeding., Hepatomegaly, Eigastric discomfort, Dizziness, Urticaria, Gastric ulceration, Cerebral hemorrhage, Respiratory alkalosis, Airway obstruction, Tinnitus

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