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Caffeine is used in combination with pain killers (aspirin and paracetamol) to ease pain that includes headache, migraine, neuralgia, toothache, sore throat, period pains, relief of sprains, strains, rheumatic pain, muscular aches and pains, joint swelling and stiffness, influenza, feverishness and feverish colds. As caffeine citrate, it is used to treat absence of breathing seen in newborns (primary apnea of premature newborns).

Caffeine is a drug which belongs to a group of medicines called methylxanthines. Caffeine acts against a chemical called adenosine in the body, and thereby reduces pain. Caffeine also stimulates the brain (central nervous system), heart, and muscles and improves the drive to breathe.

Restlessness, Can cause tremors and fluttering sensation in the chest . in higher doses, Abdominal pain, Caffeine causes cns stimulation, Confusion, Stomach pain, Swelling and redness at the site of infusion.rare: severe allergic reaction.frequency not known: serious intestinal disease with bloody stools and all other side-effects mentioned with the tablet formulation., Muscle twitching, However, When caffeine is taken as a combination tablet with pain-killers, Anxiety, Most of the side-effects are attributable to the pain-killers. caffeine, It can cause the following side-effects:common: pain, Fits, Irregular heartbeats, Sleeplessness, Increased urination and facial flushing. when given as an intravenous solution to treat primary apnea of premature infants, Nervousness, Increased heart rate, Excitement


Nimesulide is used to treat acute pain, osteoarthritis (pain and swelling of joints due to degeneration) and pain during periods.

Nimesulide belongs to a class of medications called non-steroidal anti-inflammatory drugs (NSAIDs) which works by blocking the production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation.

Gastritis, Hypersensitivity reactions., Nausea, Constipation, Breathlessness, Abnormal blood counts, Itching, High blood pressure, Diarrhea, Increased sweating and swelling, Dizziness, Rash, Vomiting and increased level of liver enzymes, Anemia, Gas

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