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Ciclesonide

Asthma, for the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older.

Ciclesonide reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Ciclesonide is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.

Rash and eczema, Dryness, Bad taste, Paradoxical bronchospasm, Hoarse voice, Inflammation and irritation at application site, Cough after inhalation., Burning

Formoterol

Formoterol is used for ?treatment of wheezing, shortness of breath and breathing difficulties caused by asthma or chronic obstructive pulmonary disorder (COPD) It is also used to treat bronchospasm (constriction of air passages) in people with night time asthma.

Formoterol belongs to a class of medication called long acting beta agonists. It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe.

Fainting, Stuffy or runny nose and sore throat, Hoarseness, Difficulty in breathing or swallowing, Nausea, Extreme tiredness, Swelling of any body part, Heartburn, Vomiting, Itching, Coughing or tightness in chest immediately after formoterol inhalation, Stomach pain, Difficulty in falling or staying asleep, Diarrhea, Back pain, Dizziness, Nervousness, Chest pain, Rash, Uncontrollable shaking of a body part, Lightheadedness, Muscle cramps, Dry mouth, Headache, Seizures.

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